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NEWS RELEASE                                                                                    January 2022

Winning Orders at the 1000 Largest Pharma Companies

Pharma Prospects provides suppliers of air, water, and energy (AWE) products with the ability to directly pursue the 1,0000 largest pharmaceutical prospects. This service can be furnished as part of a bigger initiative to win the orders. An example is plasma fractionation. This niche accounted for just under 10% of the AWE product sales to the industry of $35 billion in 2022.


The plasma fractionation market is growing at more than 6% per year. CSL and Grifols generate over 40% of the industry revenues. Takeda, Octapharma, and Kedrion are also among the top ten suppliers. The air, water, energy product opportunities at each company have to take into consideration other products and also contract  manufacturing.

Most of the $8 billion in revenues generated by CSL are tied to fractionation products. On the other hand Takeda with revenues of $32 billion is a larger AWE product purchaser even though their fractionation related sales are less than $3 billion.

The opportunity is also continually shaped by technology advances. GEA has a new separator.  Filter press suppliers are automating to decrease total cost of ownership. The future market for each of these competing products needs to be continually assessed with a lowest total cost of ownership (LTCO) analysis.

The LTCO analysis is being created in an Industrial Internet of Wisdom (IIoW) Causation Loop.  This includes fractionation articles appearing in many magazines as explained at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1692-nr2678

Pharma Prospects provides suppliers of Air, Water, Energy Products with analyses of the purchasers along with semiweekly project and market news. The extensive profiles are updated periodically.  A convenient search displays all the recent news on any of the purchasers.

This service is part of a bigger program which provides detailed forecasting of each product at each major prospect. Products and industry segments are shown at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1688-nr2674

for more information on Pharma Prospects click on http://home.mcilvainecompany.com/index.php/databases/83ai-pharma-prospects

Bob McIlvaine can answer your questions at This email address is being protected from spambots. You need JavaScript enabled to view it..  His cell is 847 226 2391.

NEWS RELEASE                                                                                    December 2021

IIoW Collaboration will Result in Huge Benefits for Suppliers and Purchasers of AWE Products

Suppliers of high-performance air, water, and energy (AWE) products could raise revenues by $50 billion and purchasers could reduce total cost of ownership by $100 billion if there was coordination to create an Industrial Internet of Wisdom (IIoW). pic1

Management consulants can expand to provide continuous support for their clients to achieve this goal.

Market analysts  will need to make accurate forecasts in each niche based on reiiable cost of ownership factors.

Media and event organizers will need to expand their scope to provide the basis for decision making and purchase and not just education and problem solving.

For example a plasma fractionation manufacturer is facing  the confusing choice between depth filtration and centrifugation. An IIoW proram is making this choice easier.

The Non-wovens Industry Association (INDA), International Filtration News (IFN), FiltXPO and McIlvaine are creating an Industrial Internet of Wisdom on Plasma Fractionaton Filtration.

The next issue of IFN will include an article on the cost of ownership factors for fractionation processes requiring filtration and purification. There is a link to a backgrouund document with extensive analysis by consulants and others.

An effort is underway to create a route map on plasma fractionation at FiltXPO in Miami at the end of March. It will connect speakers, exhibitors and attendees. McIlvaine has created route maps at previous FiltXPO, PowerGen, and WEFTEC exhibitions.

McIlvaine and IFN have teamed to provide a True Cost analysis in each issue of the magazine. In the case of HVAC filters IFN has been providing extensive coverage in articles which are easily retrieved.

With IIoW there is the connection to these past articles. The links along with a summary of the important cost of ownership insights have been prepared and are explained at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1693-nr2679

Management consultants have the opportunity to provide continuous rather than periodic support for their clients (suppliers or purchasers). The technology, politics, and competition can quickly obsolese the best of studies.  Continuing guidance on IIoW is needed.

Forecasters such as McIlvaine need to provide analysis of the cost of ownership factors of each product in each niche and even to the level of individual larger purchasers and groups of small purchasers.

Purchasers need to be active participants. General purpose product purchase decisions can be made at the plant level. But buying a higher priced product with the lowest total cost of ownership requires lots of effort. IIoW reduces the effort. Many companies have found that in house expertise and centralized decison making is necessary. Intel, BASF, and Arcelor Mittal are examples of companies with individuals assigned to insuring Lowest Total Cost of Ownership LTCO purchases.

The value of the IIoW initiative by purchsers was demonstrated by BHE Energy and McIlvaine http://www.mcilvainecompany.com/BHPG/subscriber/Default.htm

For IIoW to achieve maximum effectiveness it needs to be structured in the same manner as IIoT. This entails the adoption of commony used and accepted segmentation.

Relative to applications, the starting point can be the NAICS codes. The challenge comes in agreeing on the second level of segmentation. Should it be sugar or should cane and beet sugar have equal status with plasma fractionaton, and green hydrogen. McIlvaine efforts on this are shown at http://www.mcilvainecompany.com/Decision_Tree/subscriber/Tree/Default.htm

The identification of supplier companies is complicated by name changes and unique names for some divisions. It is further complicated by language. Therefore McIlvaine developed a unique number for each supplier.


The segmentation by product is challenging. Associations such as Hydraulic Institute (pumps) and Valve Users along with exhibition organizers such as Achema, IFAT, and Filtech can collaborate to create product segmentations which are granular enough to describe specific products in each process and application.

IIoW is all about connecton of clearly defined segments. There has been extensive collaboration to create IIoT. The same level of collaboratiion is needed to create IIoW for AWE products and services.

Bob McIlvaine is available to discuss ways various companies can collaborate in this initiative.  You can contact him at 847 226 2391 or This email address is being protected from spambots. You need JavaScript enabled to view it.

NEWS RELEASE                                                                                    December 2021

Blood Plasma Fractionation as an Example of a Path to Greater Profits for Air, Water and Energy (AWE) Suppliers

 Lowering the total cost of ownership for AWE products used in blood fractionation  can increase supplier EBITA. The McIlvaine initiative explaining this may be found at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1691-nr2677

McIlvaine’s primary role is to  generate the millions of AWE forecasts and competitor analyses needed by suppliers.  This is only possible with the Industrial Internet of Wisdom (IIoW)  which relies on knowledge generated by the media, associations and conference organizers.

Blood Plasma is a significant AWE market with innovation driving higher EBITA.

Revenues are approaching $40 billion per year. The top 10 producers account for more than 50 million liters per year.

Products include immunoglobulins, coagulation factor concentrates, albumins, protease inhibitors, and other products.

Processes include fractionation, concentration, pre- and post-virus inactivation, purification and buffer production, storage and distribution.

CRB, a provider of integrated systems for the biotechnology industry,  has given a number of AWE insights to pursue including

  • Pre-built cleanroom wall systems and prefabricated pipe racks for hygienic piping
  • Alternative separation choices
    • Centrifuges (disc or other)
    • Depth filters (filter press, cartridge, rotating disc)
    • Chromatography

Instrumentation revenues are affected by equipment choices but can also drive them. For example CRB  believes that better automated filter presses will gain market share from centrifuges. 

IIoT & Remote O&M includes guide, control, and measure products. It provides the needed total cost of ownership factors for components and consumables. It therefore should  be used for purchasing decisions.

New developments need continuous assessment. GEA has introduced its fully automatic separator, the hycon®, which enables one-touch production for separation of blood plasma and plasma proteins in cleanroom applications.

Filtration media choices are crucial. Depth filters are the first choice for the separation of precipitates and clarification processes in dedicated fractionation steps according to Eaton. Because proteins and process parameters, such as ethanol concentration and pH vary throughout the process, it is essential to choose the right filter media for the appropriate process.

EMD Millipore recommends Single-Pass Tangential Flow Filtration (SPTFF) for concentrating a plasma-derived Immunoglobulin G (IgG) solution from 10% to 20%. Alternative filter choices have different pressure requirements. This affects pump and valve selection.

Pall tangential cross flow filtration is a popular option.

The pursuit of wisdom for blood fractionation AWE will be pursued on a continuing  basis. It will include articles to be published.

 Articles: February - March 2022

  • International Filtration News: True Cost of Filters, Separators and Media for Plasma Fractionation (McIlvaine True Cost articles appear in each issue)
  • Valve World Americas: Process and CIP Valves for Plasma Fractionation
  • Pump Engineer: Pumps for processing, cooling and CIP in Plasma Fractionation
  • Hose & Coupling: H&C for processing, cooling and CIP in Plasma Fractionation
  • Stainless Steel World Americas: Stainless Steel for processing, cooling and CIP in Plasma Fractionation

Exhibitions: March

FILTEXPO, March 29-31, Miami. Route map to speakers, exhibitors and attending experts who have wisdom relative to plasma fractionation filters and media

Articles and Exhibitions:  April 2022 and subsequently

There are plans for additional articles in cleanroom and pharmaceutical magazines. Mark Allen Group through Filtration and Separation is a sponsor of FILTEXPO. It also owns World Pumps which will be contacted for future articles.

The IIoW approach for bioethanol is explained at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1690-nr2676

The niches in the pharmaceutical industry are listed at http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1688-nr2674

For more information on this program contact Bob McIlvaine at This email address is being protected from spambots. You need JavaScript enabled to view it.  cell  847 226 2391

NEWS RELEASE                                                                                    December 2021

HVAC Filter Markets Shaped by Cost Perceptions

The importance of indoor air quality has risen greatly with COVID and now the Omicron variant.  Demand for higher efficiency air filters has taxed suppliers. Questions relative to expansion are necessarily based on the course of the disease and technology developments. McIlvaine is continually seeking knowledge relative to HVAC filters in order to predict the markets. Sources include conferences, publications and insights from researchers on every continent.

Tyler Smith of Johnson Controls was a speaker at a recent WFI conference where he emphasized rating HVAC performance compared to outdoor air. This performance based  evaluation was the reason Bob Burkhead, a filter testing company CEO invested in a recirculating room system which tests performance over time.

Cleanroom experts have a unique perspective. They would say “why not rate performance compared to an ISO 9 cleanroom. This definition is precise in terms of the number of allowable particles of various sizes.

The semiconductor industry has unique insights. They require air 100 times cleaner than a pharmaceutical facility and 500,000 times cleaner than typical ambient air.

There are two magazines and two upcoming exhibitions where substantial insights will be gained. The exhibitions are

  • Filtech slated for Cologne, Germany March 8-10. There are 450 exhibitors making it the largest display for HVAC filters and media.
  • FILTXPO will be held in Miami, FL March 29-30. At previous events McIlvaine has prepared route maps to allow people to arrange visits to booths and speeches. One on HVAC filters is now in preparation.
  • Filtration and Separation has a very powerful article retrieval system with 163 articles on HVAC. https://www.filtsep.com/search?query=HVAC
  • International Filtration News (IFN) is a publication of INDA. McIlvaine has written a true cost column in every issue in the last several years.

The article in the July 2021 issue is on a decision guide to HVAC filters  https://www.filtnews.com/the-value-of-hvac-filters-has-risen/

This guide relies on information from previous issues. There is a link to a summary McIlvaine prepared of past HVAC articles.


This summary has an abstract and a link to each article in IFN. There is also the following  takeaway by McIlvaine.  

  • Lowest total cost of ownership needs to include the total cleanliness effect on the space. It will be cumulative and can involve multiple filters.
  • The deterioration in the electrostatic charge over time is a Total Cost of Ownership (TCO) factor which is debated based on time and dust loading as well as specific media characteristics.
  • Recognizing when a prefilter is required and equally important, when you can go without one, is a key to improving your TCO.
  • A database of energy costs in each country and in major regions of the U.S. would be very beneficial. This could be a uniform basis for determination of cost of ownership.
  • The balance between pressure drops and dust-loading capacities must be considered, assuming the filters are similarly priced.
  • Some of the same Lowest Total Cost of Ownership (LTCO) advantages for nanofibers in mobility applications can also be the case for stationary HVAC applications.
  • Are the LTCO factors for cabin air also valid for HVAC Filters?
  • Low pressure drop and no fiber shedding. This is important for cleanrooms but how important is fiber shedding in HVAC?
  • The Well Health Safety Seal assigns a value to life quality in the total cost of ownership. QELD developed by McIlvaine is a unique metric for better determining life quality impacts.
  • The cost of upgrading filters can include major system modifications.
  • Perceived life quality is improved with HEPA HVAC filters. If the installation costs and energy consumption are low, then the higher first cost is not significant.
  • In the future greater weight will be placed on the negative costs of air filter ownership (life quality benefits which offset costs).
  • Lowest total cost of ownership can be achieved by a filter supplier who provides sensors and a solution for the life of the filter instead of just offering the filter.
  • How useful is the MERV-A rating in LTCO evaluations?
  • Electrostatic charging methods differ. This impacts both the variety of media which can be charged and the effectiveness.
  • Improvements in melt blown and other media need to be continually assessed.
  • Can nanofibers offer superior efficiency while comparing in durability and energy consumption?

As can be seen from these articles there are many factors to consider in filter selection.  The best decision today may not be the best one tomorrow as variables such as new virus variations and technology improvements develop.

The magazines and conferences are an invaluable resource for decision making. The challenge is to make the information accessible and utilized.  

The main goal for the Mcilvaine Company is to fully understand the TCO factors in each niche in order to make market forecasts.  However, unless the end user also relies on the same TCO factors as McIlvaine, the forecasts will be inaccurate. 

Therefore McIlvaine will continue to collaborate with the media to establish a common set of TCO factors in each niche. There are 1000s of such air, water, energy niches. Information establishing common TCO factors in a number of niches is shown on the Holistic Marketing Program page at http://home.mcilvainecompany.com/index.php/30-general/1658-holistic-content-marketing-program

More information on specific reports is found under “Markets” at the top of www.mcilvainecompany.com

Bob McIlvaine can answer your questions at  This email address is being protected from spambots. You need JavaScript enabled to view it.. His cell is 847 226 2391

NEWS RELEASE                                                                                    December 2021

Increase Air, Water, Energy (AWE) Profits One Application at a Time

The Most Profitable Market (MPM) Program entails

  • Analyzing the unique aspects of each of your products
  • Determining which industries have the largest potential
  • Quantifying your product superiority in the relevant applications within the industry
  • Execute a sales strategy to validate the product superiority and focus on those purchasers who will most benefit.

Implementation of the MPM program promises to greatly increase EBITA for those companies with superior products. The program is explained at www.mcilvainecompany.com

The program can be implemented incrementally using the low hanging fruit method. There are hundreds of specific industries and multiple processes within each. Since the location of the individual fruit is not known and the cost and time to locate each one is high the initial choice is a difficult one.

Company personnel have superior knowledge relative to niches where they are active. This knowledge can be combined with McIlvaine analysis of the size and growth of multi niche segments to select the initial targets.

For any individual product the following questions need to be answered.

  • How big is the market?
  • How fast is it growing?
  • How superior is the product?
  • Are the resources available to validate the advantage, make the sale and provide what was promised?

These questions can be addressed for several alternative low hanging fruit candidates and the program initiated for the most attractive one.

Decanter centrifuges in bioethanol are used as  an example http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1690-nr2676

Here are the program steps.


Once the program to pursue the lowest hanging fruit is successful the scope can be expanded until all opportunities are analyzed. The plan should be flexible as external developments  alter the profitability potential.

For a specific product it is necessary to analyze each application within an industry where total cost of ownership factors will differ.

More than 40 segments of the pharmaceutical industry are identified as shown at  http://home.mcilvainecompany.com/index.php/other-services/free-news/news-releases/47-uncategorised/news/1688-nr2674

Food and beverage revenues for 24 segments are the starting point for analysis. There is a 10 to 1 variation in the AWE revenues per dollar of  customer revenue among the various food products.


Industry revenues are at least a starting point for estimating both the total market and the potential for individual prospects


There are 10 major segments of the energy industry which have significant potential for AWE products. Some of these such as hydrogen and biomass are fast growing.


Summaries of many applications are shown at http://home.mcilvainecompany.com/index.php/30-general/1658-holistic-content-marketing-program

The McIlvaine company offers a combination of market reports and custom consulting services to help AWE product and service suppliers pursue the MPM. This includes leveraging of internal resources and the acquisition of companies with the most valuable synergies.

The market reports are described at www.mcilvainecompany.com under the heading “Markets” at the top of the page.

Bob McIlvaine can answer your questions at This email address is being protected from spambots. You need JavaScript enabled to view it.  or cell: 847 226 2391


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