NEWS RELEASE                                                                                    December 2021

Blood Plasma Fractionation as an Example of a Path to Greater Profits for Air, Water and Energy (AWE) Suppliers

 Lowering the total cost of ownership for AWE products used in blood fractionation  can increase supplier EBITA. The McIlvaine initiative explaining this may be found at

McIlvaine’s primary role is to  generate the millions of AWE forecasts and competitor analyses needed by suppliers.  This is only possible with the Industrial Internet of Wisdom (IIoW)  which relies on knowledge generated by the media, associations and conference organizers.

Blood Plasma is a significant AWE market with innovation driving higher EBITA.

Revenues are approaching $40 billion per year. The top 10 producers account for more than 50 million liters per year.

Products include immunoglobulins, coagulation factor concentrates, albumins, protease inhibitors, and other products.

Processes include fractionation, concentration, pre- and post-virus inactivation, purification and buffer production, storage and distribution.

CRB, a provider of integrated systems for the biotechnology industry,  has given a number of AWE insights to pursue including

  • Pre-built cleanroom wall systems and prefabricated pipe racks for hygienic piping
  • Alternative separation choices
    • Centrifuges (disc or other)
    • Depth filters (filter press, cartridge, rotating disc)
    • Chromatography

Instrumentation revenues are affected by equipment choices but can also drive them. For example CRB  believes that better automated filter presses will gain market share from centrifuges. 

IIoT & Remote O&M includes guide, control, and measure products. It provides the needed total cost of ownership factors for components and consumables. It therefore should  be used for purchasing decisions.

New developments need continuous assessment. GEA has introduced its fully automatic separator, the hycon®, which enables one-touch production for separation of blood plasma and plasma proteins in cleanroom applications.

Filtration media choices are crucial. Depth filters are the first choice for the separation of precipitates and clarification processes in dedicated fractionation steps according to Eaton. Because proteins and process parameters, such as ethanol concentration and pH vary throughout the process, it is essential to choose the right filter media for the appropriate process.

EMD Millipore recommends Single-Pass Tangential Flow Filtration (SPTFF) for concentrating a plasma-derived Immunoglobulin G (IgG) solution from 10% to 20%. Alternative filter choices have different pressure requirements. This affects pump and valve selection.

Pall tangential cross flow filtration is a popular option.

The pursuit of wisdom for blood fractionation AWE will be pursued on a continuing  basis. It will include articles to be published.

 Articles: February - March 2022

  • International Filtration News: True Cost of Filters, Separators and Media for Plasma Fractionation (McIlvaine True Cost articles appear in each issue)
  • Valve World Americas: Process and CIP Valves for Plasma Fractionation
  • Pump Engineer: Pumps for processing, cooling and CIP in Plasma Fractionation
  • Hose & Coupling: H&C for processing, cooling and CIP in Plasma Fractionation
  • Stainless Steel World Americas: Stainless Steel for processing, cooling and CIP in Plasma Fractionation

Exhibitions: March

FILTEXPO, March 29-31, Miami. Route map to speakers, exhibitors and attending experts who have wisdom relative to plasma fractionation filters and media

Articles and Exhibitions:  April 2022 and subsequently

There are plans for additional articles in cleanroom and pharmaceutical magazines. Mark Allen Group through Filtration and Separation is a sponsor of FILTEXPO. It also owns World Pumps which will be contacted for future articles.

The IIoW approach for bioethanol is explained at

The niches in the pharmaceutical industry are listed at

For more information on this program contact Bob McIlvaine at This email address is being protected from spambots. You need JavaScript enabled to view it.  cell  847 226 2391